Journal article
Functional crosstalk between type I and II interferon through the regulated expression of STAT1
DJ Gough, NL Messina, L Hii, JA Gould, K Sabapathy, APS Robertson, JA Trapani, DE Levy, PJ Hertzog, CJP Clarke, RW Johnstone
Plos Biology | Published : 2010
Abstract
Autocrine priming of cells by small quantities of constitutively produced type I interferon (IFN) is a well-known phenomenon. In the absence of type I IFN priming, cells display attenuated responses to other cytokines, such as anti-viral protection in response to IFNc. This phenomenon was proposed to be because IFNa/b receptor1 (IFNAR1) is a component of the IFNc receptor (IFNGR), but our new data are more consistent with a previously proposed model indicating that regulated expression of STAT1 may also play a critical role in the priming process. Initially, we noticed that DNA binding activity of STAT1 was attenuated in c-Jun-/- fibroblasts because they expressed lower levels of STAT1 than ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by National Health and Medical Research Council (NHMRC) program (454569) and project grants (506970). RWJ is a Pfizer Australia Senior Research Fellow and a Senior Research Fellow of the NHMRC of Australia. PJH is a Principal Research Fellow of NHMRC of Australia. JAT is a Senior Principal Research Fellow of NHMRC Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.